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Click on the headings below to see example data and protocols.

REPOLARISATION ASSAYS

VENTRICULAR MYOCYTES

Protocol conditions

Effects of standard comparator compounds on APD

Effects of compounds which alter action potential configuration

Effects of compounds which shorten APD



DELAYED RECTIFIER CURRENT IK ASSAYS

hERG CHANNEL TAIL CURRENT ASSAYS

Protocol conditions

Effects of comparator compounds on hERG channel tail current

IKr ASSAYS
VENTRICULAR MYOCYTES
WHOLE-CELL PATCH-CLAMP CONDITIONS

Protocol conditions

Effects of comparator compounds on IKr

IKr ASSAYS
VENTRICULAR MYOCYTES
SWITCH-CLAMP CONDITIONS

Protocol conditions

Effects of comparator compounds on IKr



LANGENDORFF WHOLE HEART ASSAYS

Protocol conditions



L-TYPE CALCIUM CURRENT ASSAYS

Protocol conditions

Effects of comparator compounds on ICa



GAP JUNCTIONAL CONDUCTANCE ASSAYS

Protocol conditions

Effects of gap junction uncouplers

 

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