Setting standards for the investigation of drug effects on cardiac tissue

Specialists in Cardiac Research

OCP Ltd specialises in carrying out the tests that are now required by drug regulatory authorities to assess the potential of new pharmaceuticals to cause delayed ventricular repolarisation; a process that is associated with QT prolongation and an increased propensity to induce cardiac arrhythmias.

Focusing on yours Specific Research needs

OCP Ltd's expertise is based on more than twenty years experience with a variety of electrophysiological techniques. We specialise in microelectrode and patch-clamp recording applied to:

	Pharmacological profiling Repolarisation assays (Purkinje fibre, ventricular myocyte) hERG Channel assays (hERG / HEK293 cells, native IKr) Langendorff QT assays >> more information
	Drug Development Specific Ion Channel assays (ICa, IKr, IKs, INa. Gap Junctional conductance) >> more information

Whilst OCP specialises in the above techniques we also offer additional contract research services using a variety of other cardiac preparations such as isolated atria and papillary muscle preparations. The OCP development program is designed to develop new assay procedures that fit your needs.

Listening to your needs: A Flexible service

OCP Ltd has a flexible approach and would be very happy to discuss any specialist applications required by the customer. For example we have considerable expertise in isolating and recording from myocytes isolated from any region of the heart (e.g. sub-endocardial, sub-epicardial regions).